Set in 1977 Los Angeles, this neo-noir buddy comedy follows a down-on-his-luck private eye (Ryan Gosling) and a hired enforcer (Russell Crowe) who team up to investigate a missing girl and a conspiracy. While the era is often associated with excess, including drug culture, the film focuses more on the detective work, the crime plot, and the hilarious dynamic between Gosling and Crowe. Directed by Shane Black, known for his witty dialogue and action-comedy blend, the film delivers plenty of laughs and stylish action sequences. Drugs are present as part of the period setting and plot, but they aren't the source of the film's core comedic engine.

Based on the true story of George Jung, an American cocaine trafficker who worked with the Medellín Cartel. Johnny Depp delivers a compelling performance as Jung, charting his rise and fall in the drug trade. Directed by Ted Demme, the film provides a stylish look at the cocaine boom of the 1970s and 80s. While it deals heavily with the world of drugs and smuggling, Blow is primarily a biographical crime drama focused on Jung's life and relationships rather than a comedy. It's a fascinating, albeit tragic, look at the human cost of the drug trade.

Danny Boyle's acclaimed film follows a group of heroin addicts in Edinburgh during the late 1980s. While its subject matter is dark and serious, the film is infused with moments of dark humor, surrealism, and biting satire. Ewan McGregor stars as Renton, navigating addiction alongside a memorable cast of characters. The film is known for its distinctive visual style, iconic soundtrack, and unflinching portrayal of drug use. It's a powerful, thought-provoking film that uses dark comedy to explore the grim realities of addiction, making it less of a 'laugh riot' and more of a critically acclaimed cult classic with comedic elements.

Inspired by the incredible true story of Barry Seal, a pilot who became a drug smuggler for the Medellín Cartel and later an informant for the CIA. Tom Cruise stars as Seal, bringing a charismatic, devil-may-care energy to the role that injects the film with a sense of dark humor and adventure. Directed by Doug Liman (Edge of Tomorrow), the movie moves at a brisk pace, highlighting the unbelievable nature of Seal's double life. While it deals with serious themes of crime and politics, Cruise's performance and the often absurd situations Seal finds himself in lend it a definite comedic edge.

A hilarious reboot of the classic TV series, this film sees two young, incompetent cops go undercover in a high school to bust a drug ring. Channing Tatum and Jonah Hill have surprisingly fantastic comedic chemistry as the mismatched partners forced to relive their awkward teenage years. The movie constantly pokes fun at reboots and action movie tropes, delivering clever meta-humor alongside slapstick and fish-out-of-water gags. While the drug plot is the driving force, the comedy comes from the characters navigating high school cliques and their own insecurities, making it a smart and funny action-comedy.

The Coen Brothers deliver a cult classic that blends mistaken identity, kidnapping, bowling, and a lot of White Russians. Jeff Bridges stars as Jeffrey 'The Dude' Lebowski, an unemployed slacker whose life is turned upside down when he's mistaken for a millionaire with the same name. The Dude's laid-back, weed-smoking philosophy is central to his character and many of the film's most comedic moments come from his interactions with the absurd world around him, particularly his bowling buddies played by John Goodman and Steve Buscemi. It's a quirky, endlessly quotable film that's less about the plot and more about enjoying the ride with its eccentric characters.

Terry Gilliam's adaptation of Hunter S. Thompson's classic novel is a surreal, hallucinatory road trip through the American Dream's underbelly. Johnny Depp plays Raoul Duke (Thompson's alter ego) and Benicio Del Toro is his attorney, Dr. Gonzo, as they descend into a drug-fueled haze in Las Vegas. While it has moments of bizarre humor, it's less a straight comedy and more a darkly satirical, visually stunning exploration of excess and the counter-culture movement. The film's unique visual style and the committed, chaotic performances of the leads make it a cult classic, though it might be more unsettling than laugh-out-loud funny for some.

Martin Scorsese directs this wild, sprawling black comedy based on the true story of stockbroker Jordan Belfort. It's a relentless portrayal of excess, greed, and corruption on Wall Street, where drugs flow as freely as money. Leonardo DiCaprio gives an electrifying performance as Belfort, leading a cast that includes Jonah Hill and Margot Robbie. The film is packed with outrageous sequences and darkly comedic moments that highlight the sheer degeneracy of the lifestyle. Scorsese's dynamic filmmaking style keeps the energy high throughout its three-hour runtime, making it a dizzying and unforgettable ride through the world of high finance and even higher living.

What if your childhood teddy bear came to life and grew up to be a foul-mouthed, pot-smoking slacker? That's Ted! This comedy from Seth MacFarlane (creator of Family Guy) follows John Bennett and his sentient teddy bear, Ted, as their friendship clashes with John's adult life and relationship. Ted himself is the embodiment of the 'drugs and laughs' concept, constantly smoking weed and getting into trouble, providing much of the film's humor. Mark Wahlberg and Mila Kunis star, but Ted, voiced by MacFarlane, steals the show with his inappropriate antics and surprisingly deep bond with John.

Imagine waking up in Las Vegas with no memory of the night before, a tiger in the bathroom, and a missing groom. That's the premise of this incredibly successful comedy that redefined the 'walk of shame' movie. The entire plot is driven by the aftermath of an epic, drug-fueled (though not explicitly shown) bachelor party gone horribly wrong. The comedic chemistry between Bradley Cooper, Ed Helms, and Zach Galifianakis is undeniable, particularly Galifianakis as the eccentric Alan Garner. It's a mystery, an adventure, and a non-stop laugh riot as they try to piece together their lost night and find their friend.

A quintessential coming-of-age comedy about two high school seniors trying to score alcohol for a party before graduation. While the focus isn't solely on drugs, the pursuit of getting drunk and the general teenage recklessness fit the spirit of the query perfectly. This movie launched the careers of Jonah Hill and Michael Cera, and the dynamic between their characters, Seth and Evan, feels incredibly authentic. The breakout performance by Christopher Mintz-Plasse as McLovin' is legendary. Written by Seth Rogen and Evan Goldberg based on their own high school experiences, it captures that awkward, desperate energy of youth with hysterical precision.

What happens when a bunch of celebrity friends are high and the apocalypse hits? Pure comedic chaos, that's what! This film features a star-studded cast playing exaggerated versions of themselves, stuck in James Franco's house as the world ends. The humor is self-referential, raunchy, and incredibly effective. It's directed by Seth Rogen and Evan Goldberg, the duo behind Pineapple Express, and their signature comedic style is all over it. The improvised feel of the dialogue and the willingness of the actors to poke fun at their own images make for a truly unique and laugh-a-minute disaster movie parody. Plus, the special effects are surprisingly good for a comedy!

This action-comedy mashup takes the stoner genre and injects it with adrenaline! When a process server witnesses a murder and drops a rare strain of weed called Pineapple Express, he and his dealer are thrown into a wild chase with criminals and corrupt cops. Seth Rogen and James Franco are an absolute riot together, their on-screen rapport is dynamite. Franco even received a Golden Globe nomination for his comedic performance! The film expertly blends laugh-out-loud moments with surprisingly intense action sequences, making for a unique and wildly entertaining experience. It's more than just a comedy; it's a buddy action flick with a hazy twist.

Prepare for a hilarious journey fueled by the ultimate munchies! This film is a cornerstone of the modern stoner comedy genre, following two friends on an epic quest for White Castle burgers after a serious case of the highs. The movie fully embraces its premise with absurd situations, quirky characters, and genuinely funny gags that escalate wildly. Did you know John Cho and Kal Penn actually improvised many of their lines, adding to the natural chemistry that makes Harold and Kumar so lovable? It's a ridiculously fun ride that doesn't take itself seriously for a second, delivering laugh after laugh from start to finish.