Created by Christopher McCulloch (Jackson Publick), The Venture Bros. started as a parody of action cartoons like Jonny Quest but evolved into a complex, character-driven saga with a sprawling mythology. It follows the misadventures of the Venture family: incompetent boy adventurers Hank and Dean, their washed-up scientist father Dr. Thaddeus Venture, and their bodyguard Brock Samson. While a beloved Adult Swim staple with adult humor and occasional surreal elements, its strong emphasis on continuity, character development, and plot makes it quite different from the experimental, episodic nature of Xavier.

The Mighty Boosh is a British surreal comedy series created by Julian Barratt and Noel Fielding. It follows the bizarre adventures of zookeepers Vince Noir and Howard Moon. The show is known for its distinctive visual style, musical numbers, eccentric characters, and highly imaginative, often nonsensical, plots that blend fantasy and reality. While sharing a love for the surreal, its sketch-like structure and whimsical, often musical, tone differentiate it from the specific type of unsettling, stream-of-consciousness absurdity found in Xavier.

Created by Brendon Small and Tommy Blacha, Metalocalypse follows the lives of Dethklok, a fictional death metal band that is the most popular and influential entity on Earth. The show combines dark humor, satire of metal culture, and extreme violence with surprisingly detailed animation for Adult Swim at the time. While sharing Adult Swim's adult themes and dark comedy, its focus on music, character arcs, and a more consistent world makes it less aligned with Xavier's formless, philosophical absurdity.

Created by Jon Glaser, Delocated is a live-action mockumentary series about a man in witness protection (known only as 'Jon') who agrees to have a reality show made about his life, forcing him and his family to wear ski masks and have their voices distorted. The humor is derived from the awkwardness of the premise, the protagonist's narcissism, and the strange situations they find themselves in. While less purely surreal than Xavier, it shares a commitment to an offbeat, uncomfortable premise and a distinctive style.

From the creators of Archer, Frisky Dingo is a sharp, character-driven animated comedy about a supervillain, Killface, and his attempts to destroy the Earth, constantly interrupted by his own incompetence and the antics of the superhero Awesome-X (who is secretly billionaire Xander Crews). While it features more traditional animation and a clearer narrative than Xavier, its rapid-fire dialogue, bizarre characters, and satirical take on superhero tropes share some of the absurdist DNA found in Adult Swim programming.

A cornerstone of Adult Swim programming, Aqua Teen Hunger Force follows the bizarre, mundane adventures of three anthropomorphic fast-food items. Known for its minimalist animation, non-sequitur humor, and lack of overarching plot, the show's comedy comes from the strange interactions between the main characters and their perpetually annoyed neighbor, Carl. While less overtly experimental or philosophical than Xavier, its foundational role in establishing Adult Swim's brand of absurdist, low-budget animation makes it a relevant comparison.

Based on the comics by Tony Millionaire, The Drinky Crow Show follows a depressed, alcoholic crow and his monkey friend Uncle Gabby. Set in a world reminiscent of early 20th-century nautical aesthetics, the show deals with themes of existential angst, alcoholism, and violence through a darkly comedic and often surreal lens. The animation style is distinct, and while perhaps less overtly philosophical than Xavier, it shares a similar commitment to portraying a bleak and absurd reality with a unique visual flair.

Superjail! is an animated series set in a bizarre, intergalactic prison where the laws of physics and reality are constantly broken. Known for its hyper-violent, psychedelic animation and constantly shifting, surreal environments, the show follows the eccentric Warden and the inmates through increasingly chaotic and gruesome scenarios. While it has more traditional action and plot than Xavier, its relentless barrage of visual insanity and dark, absurdist humor places it firmly in the same Adult Swim realm of surreal chaos.

While a live-action talk show parody, The Eric Andre Show fully embodies the spirit of chaotic, unpredictable, and deeply uncomfortable absurdity. Eric Andre's interviews are notorious for their surreal pranks, non-sequiturs, and destruction of the set, often leaving guests genuinely bewildered or disturbed. The show's man-on-the-street segments are equally bizarre and confrontational. It captures the same energy of reality bending and embracing the nonsensical that makes Xavier so unique.

Another creation from Vernon Chatman and John Lee (of PFFR), The Heart, She Holler is a live-action series set in a deeply disturbing, isolated Southern Gothic town. It tells the story of a man who inherits his family's peculiar legacy. While live-action, it shares the PFFR sensibility of extreme absurdity, unsettling characters, and a narrative that feels both mythical and utterly nonsensical. The dialogue and situations are infused with the same kind of bizarre, dark humor and surreal dread that permeates Xavier.

Tim Heidecker and Eric Wareheim's magnum opus of cringe and surrealism. Tim and Eric Awesome Show, Great Job! is a sketch comedy show that deliberately employs low-fi production values, public-access aesthetics, and deliberately bad special effects. Featuring a rotating cast of bizarre characters and celebrity cameos in incredibly awkward situations, the show revels in the uncomfortable and the nonsensical. Its experimental structure, rapid-fire sketches, and commitment to absurdity make it a prime example of the kind of anti-humor and surrealism found in Xavier.

Before their 'Awesome Show', Tim Heidecker and Eric Wareheim brought us Tom Goes to the Mayor. This series uses a unique, often unsettling form of limited animation (primarily Flash and photo collage) to depict the hapless Tom Peters's attempts to start a business in Jefferton, constantly thwarted by the incompetent and bizarre Mayor. The humor is derived from excruciatingly awkward social interactions, cringe comedy, and surreal, often nonsensical, situations. It perfectly captures a sense of unease and absurdity that fans of Xavier will appreciate.

Also from the minds of PFFR, Wonder Showzen is a twisted, satirical take on educational children's television. Featuring puppets, animation, and live-action segments, it tackles controversial topics with a level of dark humor and social commentary that is truly shocking and thought-provoking. The 'Beat Kids' segments, where unsuspecting adults are interviewed by foul-mouthed children, are particularly infamous. While not animated in the same style as Xavier, its shared creators and willingness to delve into the deeply uncomfortable and surreal make it a spiritual sibling.

The one and only! Xavier: Renegade Angel is the benchmark for surreal, philosophical, and often deeply unsettling animated comedy. Created by PFFR (Vernon Chatman, John Lee, Jim Tozzi, Alyson Levy), this show follows a messianic, bird-like satyr on misguided spiritual quests. Its signature choppy, early-CGI animation style is as off-putting as it is mesmerizing, perfectly complementing the stream-of-consciousness dialogue and bizarre, often disturbing, plotlines. Each episode is a journey into the absurd, challenging conventions of storytelling and humor. It's a true fever dream of a show that defies easy categorization.